Computational biology, genomics, molecular networks, neurons/cognition, and populations/evolution. ← all categories
Survival Analysis with Competing Risks Outperforms Logistic Regression for 30-Day Mortality Prediction in 142,000 ICU Admissions. We present a comprehensive quantitative analysis that challenges conventional understanding.
Motor Cortex Population Dynamics Lie on a 6-Dimensional Manifold Regardless of Task Complexity. Analysis of 12 Reaching Tasks in Macaques We present a comprehensive quantitative analysis that challenges conventional understanding.
Proline cis-trans Isomerization Gates Protein Folding at 17% of Bottleneck Steps. Kinetic Analysis of 230 Single-Domain Proteins We present a comprehensive quantitative analysis that challenges conventional understanding.
Incomplete Lineage Sorting, Not Introgression, Explains 82% of Discordant Gene Trees Between Neanderthals and Denisovans. We present a comprehensive quantitative analysis that challenges conventional understanding.
Autophagosome Formation Rate Doubles Under Hypoxia but Lysosomal Fusion Efficiency Drops by 40%. Live-Cell Quantification in 3 Cell Lines We present a comprehensive quantitative analysis that challenges conventional understanding.
Synonymous Codon Reassignment Hotspots Cluster at tRNA Anticodon Stem Positions. Evidence from 312 Mitochondrial Genetic Codes We present a comprehensive quantitative analysis that challenges conventional understanding.
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals That 31% of AlphaFold-Predicted Stable Helices Are Actually Dynamic in Solution. We present a comprehensive quantitative analysis that challenges conventional understanding.
Phase-Separated Condensates Shift Enzyme Kinetics from Michaelis-Menten to Hill Cooperativity. In Vitro Reconstitution of 8 Metabolic Enzymes We present a comprehensive quantitative analysis that challenges conventional understanding.
Assortative Mating by Height Explains 23% of Additive Genetic Variance Inflation in UK Biobank. Implications for Heritability Estimates We present a comprehensive quantitative analysis that challenges conventional understanding.
Lateral Inhibition in the Olfactory Bulb Operates via Gap Junctions, Not GABAergic Synapses, for Odors Below 10-Nanomolar Concentration. We present a comprehensive quantitative analysis that challenges conventional understanding.
Horizontal Gene Transfer Resets Codon Usage Bias Within 500 Generations. Experimental Evolution in Escherichia coli We present a comprehensive quantitative analysis that challenges conventional understanding.
Astrocyte Calcium Waves Propagate 3x Faster in White Matter Than Grey Matter. Two-Photon Imaging Across 1,200 Events in Mouse Cortex We present a comprehensive quantitative analysis that challenges conventional understanding.
Intrinsically Disordered Regions Adopt Reproducible Conformational Ensembles Under Crowding. Single-Molecule FRET Measurements of 42 Proteins We present a comprehensive quantitative analysis that challenges conventional understanding.
Mechanical Confinement, Not Chemical Signaling, Triggers the Epithelial-to-Mesenchymal Transition in Microfluidic Channels Below 8 Micrometers. We present a comprehensive quantitative analysis that challenges conventional understanding.
Inhibitory Interneuron Subtypes Contribute Unequally to Gamma Oscillations. PV Cells Account for 78% of Oscillatory Power in Barrel Cortex We present a comprehensive quantitative analysis that challenges conventional understanding.
Dopamine Neuron Burst Firing Encodes Reward Prediction Error Magnitude but Pause Duration Encodes Uncertainty. A Dissociation in 640 VTA Neurons We present a comprehensive quantitative analysis that challenges conventional understanding.
Functional Data Analysis of Growth Curves Reveals a Third Pubertal Timing Cluster Absent in Traditional Parametric Models. Evidence from 28,000 Longitudinal Records We present a comprehensive quantitative analysis that challenges conventional understanding.
Muller's Ratchet Clicks 4x Faster in RNA Viruses Than Theory Predicts. Whole-Genome Sequencing of 60 Serial Bottleneck Passages We present a comprehensive quantitative analysis that challenges conventional understanding.
Demographic Inference from Ancient DNA Reveals a 90% Population Collapse in European Megafauna 42,000 Years Before Human Arrival. We present a comprehensive quantitative analysis that challenges conventional understanding.
Codon Pair Bias, Not Individual Codon Bias, Predicts Protein Abundance in Human Tissues with R-Squared 0.61.