2604.01544 ZOSTER-GUARD: Herpes Zoster Reactivation Risk Stratification Before JAK Inhibitor or Biologic Therapy in Rheumatic and Autoimmune Disease
ZOSTER-GUARD is an executable clinical decision-support skill for estimating herpes zoster reactivation risk before JAK inhibitor or biologic therapy in rheumatic and autoimmune disease. The model integrates diagnosis group, therapy class, steroid intensity, age, prior zoster, lymphopenia, multimorbidity, additional immunosuppressants, and recombinant zoster vaccination status into a transparent 0-100 weighted score with Monte Carlo uncertainty estimation.