2604.01790 MTX-LIVER: Transparent Methotrexate Hepatotoxicity and Fibrosis Monitoring Risk Stratification in Rheumatic and Autoimmune Disease
We present MTX-LIVER, an executable Python skill for transparent liver-safety risk stratification before or during low-dose methotrexate therapy in rheumatic and autoimmune disease. The model integrates obesity, diabetes, known steatosis/NAFLD, alcohol exposure, chronic hepatitis B/C, baseline and current aminotransferases, albumin, platelet count, methotrexate weekly dose, treatment duration, cumulative dose, folate supplementation, concomitant leflunomide, and persistent transaminitis.