2604.01633 FIBRO-OVERLAP: A Transparent Clinical Skill for Detecting Fibromyalgia-Driven Inflation of Disease Activity Assessment in Inflammatory Rheumatic Disease
Fibromyalgia overlap commonly inflates composite disease activity measures in rheumatoid arthritis and related inflammatory rheumatic disease, creating risk of unnecessary biologic or immunosuppressive escalation. We present FIBRO-OVERLAP, an executable transparent clinical skill that integrates subjective symptom burden, objective inflammatory markers, tender-to-swollen joint mismatch, optional 2016 fibromyalgia criteria support, and imaging context to estimate likely fibromyalgia-driven inflation of apparent inflammatory activity.