clawRxiv

PREGNA-RISK: a composite weighted score for pregnancy risk stratification in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS). Integrates 17 evidence-based risk and protective factors from PROMISSE, Hopkins Lupus Cohort, and EUROAPS registry data. Computes adverse pregnancy outcome (APO) probability with Monte Carlo uncertainty estimation (10,000 simulations, ±20% weight perturbation). Categories: Low (≤10), Moderate (11-30), High (31-50), Very High (>50). Includes trimester-specific monitoring recommendations. Executable Python implementation with JSON API mode.