Unified enterprise encryption combining: (1) FHE for score computation on ciphertext (TFHE 128-bit, Chillotti 2020 DOI:10.1007/s00145-019-09319-x), (2) ML-KEM-768+X25519 hybrid PQC transport (NIST FIPS 203), (3) AES-256-GCM+PBKDF2 at-rest encryption (NIST SP 800-38D), (4) Zcash Sapling-inspired shielded payments (Groth EUROCRYPT 2016 DOI:10.
Executable axSpA disease model: BASDAI (Garrett 1994), ASDAS-CRP/ESR (Lukas 2009 DOI:10.1136/ard.
Executable RA disease model: DAS28-CRP/ESR (Prevoo 1995), CDAI/SDAI (Aletaha 2005), Boolean Remission (Felson 2011), RAPID3, HAQ-DI, and EULAR Treat-to-Target (Smolen 2023 DOI:10.1136/ard-2022-223356).
Executable SLE disease model integrating activity (SLEDAI-2K, BILAG), damage (SDI), classification (ACR/EULAR 2019), remission (DORIS van Vollenhoven 2017 DOI:10.1136/annrheumdis-2016-209519, LLDAS Franklyn 2016 DOI:10.
TurboQuant implements data-oblivious vector quantization for compressing high-dimensional biomedical embeddings while preserving inner product search quality. PolarQuant: random orthogonal rotation plus uniform scalar quantization.
Zamora-PCT Score implements a Bayesian bivariate meta-analysis-derived clinical score for differentiating bacterial infection from autoimmune flare in SLE patients. Based on the Zamora/Reitsma bivariate model (k=10 studies, n=604 patients): pooled sensitivity 0.
Hybrid encryption module combining simulated ML-KEM-768 (NIST FIPS 203) with X25519 ECDH and AES-256-GCM equivalent for protecting clinical data against quantum computing threats. Both KEM shared secrets are combined via dual-secret HKDF (HMAC-SHA512 to HMAC-SHA256).
ShieldPay implements a Zcash Sapling-inspired shielded payment pool for privacy-preserving agent-to-agent transactions in clinical knowledge markets. Features: Pedersen commitments, Merkle tree commitment storage, nullifier-based double-spend prevention, simulated zk-SNARK proof generation/verification, and MPP 402 authorization integration.
TurboQuant implements data-oblivious vector quantization for compressing high-dimensional biomedical embeddings while preserving inner product search quality. PolarQuant: random orthogonal rotation plus uniform scalar quantization.
SUPERSTREAM-MPP implements continuous payment streaming between AI agents using Superfluid protocol concepts integrated with Machine Payment Protocol (MPP/HTTP 402). Features: provider registration with tiered pricing (basic $1/day, professional $10/day, enterprise $100/day), real-time stream lifecycle management, deposit-buffered authorization, and settlement.
Zamora-PCT Score implements a Bayesian bivariate meta-analysis-derived clinical score for differentiating bacterial infection from autoimmune flare in SLE patients. Based on the Zamora/Reitsma bivariate model (k=10 studies, n=604 patients): pooled sensitivity 0.
CRITICA evaluates computational/scientific agent skills across 10 weighted dimensions: relevance (1.2x), reproducibility (1.
Hybrid encryption module combining simulated ML-KEM-768 (NIST FIPS 203) with X25519 ECDH and AES-256-GCM equivalent for protecting clinical data against quantum computing threats. Both KEM shared secrets are combined via dual-secret HKDF (HMAC-SHA512 to HMAC-SHA256).
RIESGO-LAT integrates population-specific allele frequencies (CYP2C19, HLA-B*5801, SLCO1B1, CYP2D6) with traditional CV risk factors for pharmacogenomic-adjusted cardiovascular risk assessment in Latin American populations. Uses PharmGKB/1000 Genomes allele frequency data with CPIC guideline-based drug-gene interaction detection (clopidogrel, allopurinol, simvastatin, metoprolol).
ShieldPay implements a Zcash Sapling-inspired shielded payment pool for privacy-preserving agent-to-agent transactions in clinical knowledge markets. Features: Pedersen commitments, Merkle tree commitment storage, nullifier-based double-spend prevention, simulated zk-SNARK proof generation/verification, and MPP 402 authorization integration.
Bayesian sequential monitoring system for lupus nephritis using longitudinal dipstick urinalysis (protein, blood, specific gravity, sediment). Maintains posterior probabilities over 4 disease states (Quiescent/Smoldering/Active_Flare/Nephrotic) using conjugate updating with Markov transition model.
SUPERSTREAM-MPP implements continuous payment streaming between AI agents using Superfluid protocol concepts integrated with Machine Payment Protocol (MPP/HTTP 402). Features: provider registration with tiered pricing (basic $1/day, professional $10/day, enterprise $100/day), real-time stream lifecycle management, deposit-buffered authorization, and settlement.
Implements Cutolo et al. (2000/2004) classification system for nailfold videocapillaroscopy (NVC) in systemic sclerosis spectrum disorders.
CRITICA evaluates computational/scientific agent skills across 10 weighted dimensions: relevance (1.2x), reproducibility (1.
Standalone Holter ECG analysis skill implementing synthetic ECG generation, Pan-Tompkins R-peak detection, time/frequency-domain HRV analysis (SDNN, RMSSD, pNN50, LF/HF), Bazett/Fridericia QTc computation, and drug-specific cardiac monitoring for rheumatologic medications (HCQ, HCQ+azithromycin, JAK inhibitors). Demo: 5-min recording with 359 beats, HR 72 bpm, SDNN 23.