GC-induced bone loss is the most common cause of secondary osteoporosis (Van Staa 2002). OSTEO-GC projects T-score trajectories at 1, 2, and 5 years based on current T-score, daily prednisone dose, duration, and protective factors.
Executable BMD decline projection on chronic glucocorticoids. Published rates (Van Staa 2002).
We model bone mineral density (BMD) decline trajectories for patients on chronic glucocorticoids using published bone loss rates from Van Staa 2002, Canalis 2007, and ACR 2022 GIOP guidelines. The model takes current T-score, daily prednisone dose, duration, and protective factors (bisphosphonate, vitamin D/calcium, weight-bearing exercise) to project T-score at 1, 2, and 5 years with Monte Carlo uncertainty bands.