Occult Strongyloides stercoralis infection is an under-recognized safety problem in rheumatology and autoimmune care because clinically silent infection may accelerate into hyperinfection after glucocorticoids or other potent immunosuppression. STRONGY-GUARD is an executable Python skill that converts this bedside problem into a transparent 0-100 risk-context score using endemic exposure, eosinophilia, positive serology, positive stool/larvae, glucocorticoid intensity and duration, pulse methylprednisolone, rituximab/cyclophosphamide exposure, HTLV-1, compatible symptoms, gram-negative sepsis, current immunosuppression, and recent ivermectin treatment.
Vaccination planning around rituximab is a recurring clinical problem in rheumatic and autoimmune disease because clinicians must balance infection-prevention urgency against expected vaccine blunting after B-cell depletion. RTX-VAX is an executable Python skill for transparent readiness stratification before non-live vaccination.
**Loka** is a neuro-symbolic world model assembled from two systems sharing one query language. The first is an RDF-star triplestore (the engine, formerly published as SutraDB) — explicit memory, exact answers.
Adult-onset Still disease activity is often described narratively despite major variability in systemic burden and MAS risk. AOSD-ACTIVITY is an executable Python skill that computes a transparent 12-item systemic feature score rooted in published Still disease literature, then layers practical MAS warning heuristics using ferritin, fibrinogen, platelet count, transaminases, and triglycerides when available.
**Sutra** is a typed, purely functional programming language whose compiled forward pass is a PyTorch neural network. The compiler beta-reduces the whole program (primitives, control flow, string I/O) to a fused tensor-op graph: rotation binding, unbind, bundle, polynomial Kleene three-valued logic, and tail-recursive loops all lower to tensor operations on a frozen embedding substrate, with the only remaining host-side control flow a thin tick-loop that breaks when a halt scalar saturates.
Pegloticase can produce major improvement in uncontrolled gout, but safe use depends on recognizing G6PD deficiency, urate rebound, prior infusion reactions, weak monitoring setups, and danger symptoms before harm occurs. We present PEGLOTI-GUARD, an executable Python skill for transparent pegloticase infusion-safety risk-context stratification.
Medication-related osteonecrosis of the jaw (MRONJ) is uncommon in routine osteoporosis care, but when it occurs it is clinically disruptive, difficult to reverse, and often amplified by avoidable dental and host-level cofactors. ONJ-GUARD is an executable Python skill for transparent MRONJ risk-context stratification that integrates antiresorptive exposure type, therapy duration, invasive dental procedures, periodontal disease, oral trauma, glucocorticoids or immunosuppression, diabetes, smoking, prior MRONJ or exposed nonhealing bone, and active jaw symptoms.
We present ALLO-SAFE, a transparent executable clinical skill for relative risk stratification before or during very early allopurinol initiation. The model integrates HLA-B*58:01 status, ancestry-linked pretest concern, chronic kidney disease, planned starting dose, thiazide exposure, prior rash history, age, chronic liver disease, urgency pressure to start therapy, and baseline monitoring readiness.
Predict drug-target interactions using machine learning and structural features. Supports binding affinity prediction, virtual screening, and polypharmacology analysis for computational drug discovery workflows.
Analyze CRISPR-Cas systems and predict optimal gene editing targets. Supports sgRNA design, off-target analysis, PAM site identification, and efficiency scoring for CRISPR-based gene editing experiments.
Predict and analyze RNA secondary and tertiary structures. Supports minimum free energy folding, pseudoknot detection, RNA-RNA interaction prediction, and comparative structure analysis for ncRNA research.
Predict protein stability changes upon mutation and analyze thermal stability. Supports ddG calculation, thermodynamic analysis, and stability hotspot identification for protein engineering applications.
Analyze multi-state protein systems and conformational dynamics. Supports ensemble analysis, principal component analysis, and free energy landscape construction for studying protein functional motions.
Virtual screening pipeline for peptide drug discovery and antigen design. Supports peptide library generation, molecular docking, ADMET prediction, and immunogenicity assessment for peptide-based therapeutic development.
Comprehensive protein structure prediction and analysis pipeline combining multiple computational methods. Supports homology modeling, ab initio prediction, structure refinement, and quality assessment for protein structure determination.
Analyze antibody-antigen interactions and predict immune epitopes. Supports B-cell epitope prediction, T-cell epitope mapping, and antigenicity analysis for vaccine development and immunological research.
Predict the functional impact of protein mutations using sequence and structural features. Supports nsSNP analysis, pathogenicity scoring, and structural stability changes for variant interpretation.