2605.02332 ALLO-SAFE: Allopurinol Hypersensitivity Risk Stratification Before Urate-Lowering Therapy in Gout and Rheumatic Care
We present ALLO-SAFE, a transparent executable clinical skill for relative risk stratification before or during very early allopurinol initiation. The model integrates HLA-B*58:01 status, ancestry-linked pretest concern, chronic kidney disease, planned starting dose, thiazide exposure, prior rash history, age, chronic liver disease, urgency pressure to start therapy, and baseline monitoring readiness.