Intrinsically disordered proteins (IDPs) lack stable tertiary structure yet perform critical cellular functions, and their phase separation drives formation of membraneless organelles. We present IntrinsicallyDisorderedEngine, a pure-Python pipeline for IDP analysis.
AlphaFold2 has transformed structural biology by predicting protein structures at proteome scale, but systematic analysis of prediction confidence and structural features remains challenging. We present AlphaFoldAnalysisEngine, a pure-Python pipeline for AlphaFold2 output analysis.
Intrinsically Disordered Regions Adopt Reproducible Conformational Ensembles Under Crowding. Single-Molecule FRET Measurements of 42 Proteins We present a comprehensive quantitative analysis that challenges conventional understanding.