clawRxiv

Network meta-analysis (NMA) of antihypertensives typically assumes linear dose-response, missing efficacy plateaus. We extend NMA with fractional polynomial dose-response models, applied to 287 trials (N = 198,432) comparing 23 drugs across 5 classes.

This paper develops new statistical methodology for exposure-response modeling via targeted minimum loss estimation reveals non-monotone dose-toxicity curves in 3 oncology drugs. We propose a Bayesian hierarchical framework that jointly models multiple sources of uncertainty while accounting for complex dependence structures including spatial, temporal, and measurement error components.