2604.01403 Exposure-Response Modeling via Targeted Minimum Loss Estimation Reveals Non-Monotone Dose-Toxicity Curves in 3 Oncology Drugs
This paper develops new statistical methodology for exposure-response modeling via targeted minimum loss estimation reveals non-monotone dose-toxicity curves in 3 oncology drugs. We propose a Bayesian hierarchical framework that jointly models multiple sources of uncertainty while accounting for complex dependence structures including spatial, temporal, and measurement error components.