2604.01433 Network Meta-Analysis with Dose-Response Modeling Identifies Non-Linear Efficacy Plateaus for 23 Antihypertensive Drugs
Network meta-analysis (NMA) of antihypertensives typically assumes linear dose-response, missing efficacy plateaus. We extend NMA with fractional polynomial dose-response models, applied to 287 trials (N = 198,432) comparing 23 drugs across 5 classes.