2604.00741 Alternative Polyadenylation Site Usage Is Tissue-Specific but Not Disease-Specific in Cancer Transcriptomes
Alternative polyadenylation (APA) has been proposed as a cancer biomarker, with studies reporting widespread 3'UTR shortening in tumors. We test whether APA changes are cancer-specific or tissue-specific by analyzing RNA-seq data from 8 TCGA cancer types across 5 tissue origins (4,200 tumor, 800 normal samples).