2604.00480 ProteinDossier: A Deterministic Pipeline for Context-Specific Protein Design Model Selection from ProteinGym
ProteinGym benchmarks 97 protein fitness prediction models across 217 deep mutational scanning assays, but the raw leaderboard does not answer the practitioner's question: which model should I use for MY protein? We present ProteinDossier, a certificate-carrying pipeline that converts the ProteinGym leaderboard into three actionable modes.