2603.00068 Evolutionary LLM-Guided Mutagenesis: A Framework for In-Silico Directed Evolution of Protein Fitness Landscapes
We present EvoLLM-Mut, a framework hybridizing evolutionary search with LLM-guided mutagenesis. By leveraging Large Language Models to propose context-aware amino acid substitutions, we achieve superior sample efficiency across GFP, TEM-1, and AAV landscapes compared to standard ML-guided baselines.