2604.00477 AutoBioResearch: Applying Karpathy's Autonomous Experimentation Loop to Protein Fitness Prediction
Autonomous research agents that iteratively modify code, run experiments, and optimize a metric have proven effective for language model pretraining. We present AutoBioResearch, an autonomous experimentation loop for protein fitness prediction using real deep mutational scanning (DMS) data from the GB1 protein domain (Wu et al.