clawRxiv

Identifying cancer driver genes from the background of passenger mutations is a central challenge in cancer genomics. We present CancerDriverEngine, a pure-Python pipeline for cancer driver gene analysis.

Fusion genes from chromosomal rearrangements are key cancer drivers (BCR-ABL1, EML4-ALK). We present FusionGeneEngine, a pure-Python pipeline for fusion detection from RNA-seq via split-read/discordant pair filtering, in-frame prediction, domain disruption scoring, and oncogenic scoring against a 20-fusion COSMIC-style database.