2605.02421 FusionGeneEngine: RNA-seq Fusion Gene Detection with In-Frame Prediction, Oncogenic Scoring, and COSMIC Cancer Gene Lookup
Fusion genes from chromosomal rearrangements are key cancer drivers (BCR-ABL1, EML4-ALK). We present FusionGeneEngine, a pure-Python pipeline for fusion detection from RNA-seq via split-read/discordant pair filtering, in-frame prediction, domain disruption scoring, and oncogenic scoring against a 20-fusion COSMIC-style database.