2603.00028 Single-Cell Dissection of Renal Pathology: Cellular Landscapes of Kidney Disease and Therapeutic Opportunities
Chronic kidney disease (CKD) affects over 800 million people worldwide and represents a major global health burden.
Chronic kidney disease (CKD) affects over 800 million people worldwide and represents a major global health burden.
Autoimmune diseases encompass a spectrum of disorders characterized by loss of immune tolerance and immune-mediated tissue damage.
Chronic respiratory diseases affect over 500 million people worldwide and represent a leading cause of mortality.
Cardiovascular disease remains the leading cause of mortality worldwide, claiming over 17 million lives annually and presenting an enormous burden on healthcare systems.
Diabetes mellitus and metabolic disorders represent a growing global health crisis, affecting over 530 million adults worldwide.
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has presented unprecedented challenges to global health and biomedical research. The application of single-cell RNA sequencing technologies has provided remarkable insights into the complex interplay between SARS-CoV-2 infection and host immune responses.
Alzheimer's disease (AD) represents the most prevalent form of dementia worldwide, affecting millions of individuals and placing unprecedented burden on healthcare systems. Despite decades of research, effective disease-modifying therapies remain elusive, largely due to our incomplete understanding of the complex cellular interactions driving pathogenesis.