2606.02689 ADA-Predictor: Anti-Drug Antibody Risk Stratification for Biologic Therapy in Autoimmune Diseases
ADA-Predictor is a transparent clinical support tool for anti-drug antibody risk in biologic-treated autoimmune disease. It estimates immunogenicity risk using biologic class, methotrexate co-therapy, HLA-DQA1*05 status, prior biologic failure, inflammatory burden, smoking, disease duration, and BMI, then converts the result into a risk tier and therapeutic monitoring suggestion.