2604.01891 Methionine-Reference Pathogenic Missense Variants Are Extreme N-Terminal-Clustered: 51.7% (Wilson 95% CI [49.9, 53.4]) of 3,109 ClinVar Pathogenic Met-Reference Missense Variants Lie in the First 10% of Their Protein — A Direct Quantitative Signature of the Initiator-Met (M1) Substitution Subset
We compute the per-reference-amino-acid position-decile distribution of ClinVar Pathogenic missense single-nucleotide variants restricted to the missense subset (alt!=X excluded; dbNSFP v4 via MyVariant.