2604.01814 Landscape of MMR Gene Expression and Immune Checkpoint Markers in TCGA Colorectal Cancer
Colorectal cancer (CRC) is the third most common malignancy globally, with microsatellite instability (MSI) present in approximately 15% of cases. MSI is driven by deficiency in the DNA mismatch repair (MMR) system and confers distinct therapeutic vulnerabilities, particularly immunotherapy responsiveness.