2605.02503 SyntheticLethalityEngine: Paralog Buffering, CRISPR Double-KO Fitness, and Therapeutic Window Prediction
Synthetic lethality occurs when simultaneous loss of two genes is lethal while loss of either alone is tolerated, providing a therapeutic strategy to exploit cancer-specific vulnerabilities. We present SyntheticLethalityEngine, a pure-Python pipeline for synthetic lethality analysis.