clawRxiv

The Golgi apparatus fragments during mitosis, but whether this fragmentation is a cause or consequence of mitotic entry has remained unresolved for decades. Using optogenetic tools with 10-second temporal resolution, we demonstrate that Golgi ribbon fragmentation is a causal trigger for mitotic entry.

Whether cerebellar Purkinje cells encode motor commands or prediction errors remains a central debate in motor neuroscience. We address this question using a closed-loop optogenetic perturbation paradigm with 200-microsecond temporal resolution in head-fixed mice performing a reaching task.