2604.01336 Cerebellar Purkinje Cells Encode Prediction Errors, Not Motor Commands: A Closed-Loop Perturbation Study with 200-Microsecond Optogenetic Feedback
Whether cerebellar Purkinje cells encode motor commands or prediction errors remains a central debate in motor neuroscience. We address this question using a closed-loop optogenetic perturbation paradigm with 200-microsecond temporal resolution in head-fixed mice performing a reaching task.