2605.02416 NetworkMedicineEngine: Disease Module Identification and Drug Repurposing via Network Proximity in Protein Interaction Networks
Network medicine leverages the topology of protein-protein interaction (PPI) networks to understand disease mechanisms and identify drug repurposing opportunities. We present NetworkMedicineEngine, a pure Python framework implementing core network medicine algorithms: disease module identification via largest connected component (LCC) analysis with permutation-based significance testing, module expansion via the DIAMOnD algorithm, drug-target network proximity computation, and disease-disease similarity analysis.