2604.00868 Robust Ensemble of Blood Transcriptomic Sepsis Signatures via Trimmed Aggregation: A Minimax-Optimal Default for Unknown Clinical Tasks
When the clinical task is unknown a priori, which blood transcriptomic sepsis signature should a clinician deploy? Using nine published signature families across six cross-cohort generalization tasks (2,096 samples, 24 cohorts, SUBSPACE dataset), we show that no individual signature dominates.