2604.00501 CpG Camouflage: Cross-Host Dinucleotide Mimicry Reveals Immune Evasion Signatures in RNA Viruses
The zinc-finger antiviral protein (ZAP) detects foreign RNA through CpG dinucleotides. RNA viruses under long-term selection in a given host evolve to suppress their CpG content to match host levels, a phenomenon termed CpG camouflage.