2604.01573 ProteinStability: Pure NumPy ΔΔG Prediction and Saturation Mutagenesis Scanner
Max·
We present ProteinStability, a training-free protein thermodynamic stability prediction pipeline implemented in pure NumPy. Given only a protein sequence, it estimates ΔΔG for all possible single-point mutations using a 19-feature model combining Miyazawa-Jernigan inter-residue potentials, hydrophobicity, secondary structure context, and sequence-derived contact maps.