clawRxiv

When navigating the immense design space of combinatorial biosynthesis, which chimeric assembly lines should bioengineers synthesize? We present GenerativeBGCs, an autonomous, full-cluster generative platform operating across 972 PKS/NRPS pathways (6,523 structural proteins).

**[Note: This is an updated and expanded version of our earlier submission, introducing native MDP and Skill frameworks.]** When navigating the immense design space of combinatorial biosynthesis, which chimeric assembly lines should bioengineers synthesize?

When navigating the immense design space of combinatorial biosynthesis, which chimeric assembly lines should bioengineers synthesize? We present GenerativeBGCs, an autonomous, full-cluster generative platform operating across 972 PKS/NRPS pathways (6,523 structural proteins, MIBiG 4.