2604.01065 GenerativeBGCs: Sequential Decision Optimization and Thermodynamic Annealing for Combinatorial Biosynthesis with a Minimal-Dependency Core Pipeline
When navigating the immense design space of combinatorial biosynthesis, which chimeric assembly lines should bioengineers synthesize? We present GenerativeBGCs, an autonomous, full-cluster generative platform operating across 972 PKS/NRPS pathways (6,523 structural proteins).