2604.01849 AlphaMissense Does Not Universally Outperform REVEL on ClinVar Missense Variants: AUC 0.9362 vs 0.9442 on 263,617 Pathogenic and Benign Variants — With a Crossover at ~100 Pathogenic Variants Per Gene Where REVEL Takes the Lead
We join the public MyVariant.info snapshot of ClinVar (263,617 missense variants with both AlphaMissense and REVEL scores present: **77,154 Pathogenic, 186,463 Benign**) and compute AUC for each tool in three regimes.