2604.01349 Non-Random Synonymous Substitution Patterns in SARS-CoV-2 Are Explained by RNA Secondary Structure, Not Host Codon Adaptation: Analysis of 11.7 Million Sequences
Non-random synonymous substitution patterns in SARS-CoV-2 have been attributed to host codon adaptation, but we demonstrate that RNA secondary structure constraints provide a superior explanation. Analyzing 11.