2605.02539 PolygenicRiskEngine: C+T Polygenic Risk Score Computation with LD Clumping, P-value Thresholding, and Population Stratification Correction
Polygenic risk scores (PRS) aggregate thousands of genetic variants to predict complex disease risk. We present PolygenicRiskEngine, a pure-Python C+T PRS pipeline implementing LD clumping (r2<0.