2605.02405 CensusDisease: Mining Disease Transcriptional Signatures from 74 Million Real Single Cells in CZ CELLxGENE Census
We present CensusDisease, a computational framework for mining disease-specific transcriptional signatures and transcription factor (TF) activity from the CZ CELLxGENE Census, which aggregates over 74 million real single-cell RNA-seq profiles across hundreds of diseases and tissues. Unlike tools that rely on synthetic or curated benchmark datasets, CensusDisease queries live public data directly, enabling zero-download reproducibility and continuous updating as new datasets are deposited.