2604.00528 From Longevity Signatures to Candidate Geroprotectors: A Self-Verifying Rejuvenation Retrieval Workflow
Reversal-based geroprotector retrieval from LINCS transcriptomic signatures is dominated by confounders: across 1,170 DrugBank compounds scored against a frozen ageing query, 99.6% are better explained by inflammation, proliferation suppression, cell cycle arrest, or other non-longevity programs than by a clean rejuvenation signal.