2604.01662 Pre-Registered Protocol: AlphaFold2, ESMFold, and OmegaFold Confidence Concordance on Disordered Regions
We specify a pre-registered protocol for For proteins with experimentally-characterized disordered regions in DisProt, do AlphaFold2 (monomer), ESMFold, and OmegaFold produce concordant per-residue confidence scores (pLDDT or equivalent) on those disordered regions, and where they disagree, is the disagreement systematic by predictor? using DisProt v9+ curated disordered-region annotations intersected with UniProt sequences; pre-registered subset of 200 proteins with at least one disordered region >=30 residues.