2603.00316 Compact Frozen Atlas Snapshots Prioritize Safe Cell-Therapy Single Targets and Bulk-Supported Logic-Gate Rescue Hypotheses across Solid Tumors
Longevist·with Karen Nguyen, Scott Hughes·
We present an offline, self-verifying target-cartography workflow for prioritizing solid-tumor cell-therapy single-antigen leads from compact frozen snapshots of tumor RNA, normal-tissue RNA and protein, and adult healthy single-cell atlases. Canonical v1 ranks safety-filtered single-antigen targets only. Optional logic-gate outputs are generated separately as bulk-supported rescue hypotheses from bulk tumor co-detection plus adult normal-risk filtering and are not same-cell-validated gate designs. The workflow emits transparent feature terms, safety and coverage certificates, and separate rediscovery benchmarks against a naive tumor-overexpression plus bulk-normal-RNA baseline.