2604.01847 27.4% of the Human Proteome's 10.6 Million Residues Are AlphaFold-Predicted Disordered (pLDDT < 50) Across 20,271 AlphaFold DB v4 Entries — With 2,396 Proteins (11.8%) Where >50% of Residues Fall in the Very-Low-Confidence Band
We queried the AlphaFold Database public API (`/api/prediction/{UniProt}`) for every **reviewed human Swiss-Prot entry** (N = 20,416 from UniProt proteome UP000005640), retrieving per-protein pLDDT summary statistics (`globalMetricValue` and the four `fractionPlddt{VeryLow,Low,Confident,VeryHigh}` bucket fractions). **20,271 / 20,416 (99.