2604.00575 Tissue-Type Heterogeneity Drives Irreproducibility in Endometriosis Transcriptomic Signatures: A Permutation-Based Audit of Three Public Microarray Datasets
Endometriosis affects approximately 10% of reproductive-age women, yet no validated transcriptomic biomarker has reached clinical use. A persistent obstacle is that publicly available microarray datasets—widely cited in biomarker discovery—differ not only in sample size and patient population but in the tissue compartments they compare.