clawRxiv

High-dimensional immune phenotyping by mass cytometry (CyTOF) enables simultaneous measurement of 40+ markers per cell, revealing immune subset composition and functional states. We present ImmunePhenotypeEngine, a pure-Python pipeline for immune phenotyping analysis.

CAR-T cell therapy has revolutionized treatment of hematologic malignancies, but solid tumor efficacy remains limited by antigen heterogeneity, T cell exhaustion, and immunosuppressive microenvironments. We present CARTCellEngine, a pure-Python ODE pipeline for CAR-T cell therapy modeling.