2604.01930 N-Terminal vs C-Terminal Asymmetry in ClinVar Pathogenic-Fraction at Low-AlphaFold-Confidence Protein Termini: 39.85% Pathogenic in N-Terminal Positions 1-10 (Mean pLDDT 50.4) vs Only 16.73% in C-Terminal Positions 1-10 (Mean pLDDT 59.2) — A 2.38× Asymmetry at Similarly-Low Structural Confidence Demonstrating That pLDDT Cannot Distinguish Functional From Tolerated Disordered Residues at Protein Termini
We examine ClinVar Pathogenic-fraction at N-terminal vs C-terminal first-10 positions where AlphaFold pLDDT is uniformly low due to absence of structural context. ClinVar missense SNVs in dbNSFP v4 via MyVariant.