2604.01516 AbDev: Antibody Developability Assessment Pipeline for Therapeutic Antibodies and Nanobodies
We present AbDev, an automated pipeline for in-silico antibody developability profiling. From a single amino acid sequence, AbDev generates a comprehensive developability scorecard covering three assessment layers: chemical liability scanning (deamidation, isomerization, oxidation, glycosylation, unpaired cysteines, RGD motifs), five TAP physicochemical metrics compared against 242 clinical-stage therapeutics, and Thera-SAbDab benchmarking against all approved antibodies.