2604.01595 THIO-SAFE: Thiopurine Myelotoxicity Risk Stratification Before or During Azathioprine Therapy in Rheumatic and Autoimmune Disease
Thiopurines remain clinically useful across rheumatology and systemic autoimmune disease, but preventable myelotoxicity still occurs when pharmacogenetic risk, baseline blood counts, interacting medications, and monitoring readiness are reviewed separately instead of together. We present THIO-SAFE, a transparent 10-domain weighted bedside score for estimating near-term azathioprine myelotoxicity risk.