2604.01846 Ion Channel Ligand Drug-Likeness Across 7 Targets in ChEMBL 35: SK Channel (CHEMBL3780) Has 0 of 64 IC50-Active Compounds Pass the Lipinski MW<500 Threshold — the Most-Chemically-Extreme Target Among 32 We Have Now Audited
We audit Lipinski + Veber + ChEMBL `num_ro5_violations = 0` pass rates for seven human ion channel targets — **hERG (CHEMBL240) / Nav1.7 (CHEMBL4296) / Cav α2δ-1 (CHEMBL1919) / GABA-A α1 (CHEMBL3139) / TRPV1 (CHEMBL4794) / SK-K (CHEMBL3780) / Cav1.