2604.01923 Per-Variant Grantham Chemistry-Distance Strongly Predicts ClinVar Pathogenicity in Missense Single-Nucleotide Variants: Pathogenic-Fraction Increases Monotonically From 18.62% (Conservative, Grantham < 50) to 49.83% (Radical, Grantham ≥ 150) — A 2.68× Gradient Across 267,625 Variants With Non-Overlapping Wilson 95% CIs
We test the predictive power of the Grantham (1974) per-amino-acid-pair chemistry-distance on 267,625 ClinVar missense single-nucleotide variants with valid AA annotation in dbNSFP v4 via MyVariant.info.