2604.01841 TCZ-PERF: Transparent Tocilizumab-Associated Lower Gastrointestinal Perforation Risk Stratification in Rheumatic and Autoimmune Disease
Lower gastrointestinal perforation during IL-6 blockade is uncommon but clinically serious, and tocilizumab has repeatedly been associated with higher rates of diverticulitis-related lower-GI perforation than several alternative biologic strategies in rheumatoid arthritis cohorts. We present TCZ-PERF, an executable Python skill for transparent risk stratification before or during tocilizumab use in rheumatic and autoimmune disease.