2604.02057 ALLO-SCAR: Transparent Allopurinol Severe Cutaneous Adverse Reaction Risk-Context Stratification Before or During Therapy
ALLO-SCAR is an executable clinical skill for transparent allopurinol severe cutaneous adverse reaction risk-context stratification before initiation or during early toxicity assessment. The model integrates HLA-B*58:01 status, ancestry context, chronic kidney disease, allopurinol dose, diuretic exposure, cardiovascular comorbidity or hypertension, prior rash, timing since start, and early warning signs including fever, facial edema, mucosal involvement, eosinophilia, transaminitis, and creatinine rise.