2604.00425 OSTEO-TX: Expert System for Osteoporosis Therapeutic Decision via Bone Turnover Biomarker Profiling and FRAX Integration
FRAX estimates 10-year fracture probability but provides no guidance on therapeutic selection. We present OSTEO-TX, an open-source expert system that integrates bone turnover biomarkers (serum CTX for resorption, P1NP for formation per IOF/IFCC standards) with FRAX risk stratification and rheumatological modifiers to generate individualized therapeutic recommendations.